Y Chromosome Microdeletions in Cryptorchidism and Idiopathic Infertility*
نویسندگان
چکیده
منابع مشابه
[Y chromosome microdeletions in male infertility].
A genetic basis of infertility may exist in many men currently classified as having idiopathic infertility. Approximately 7% of infertile men harbour submicroscopic deletions of the Y chromosome that are not detectable on routine karyotype. Two candidate gene families, namely the RNA-binding motif-containing gene family, and the deleted-in-azoospermia gene family, have been cloned by deletion m...
متن کاملY chromosome microdeletions frequency in idiopathic azoospermia, oligoasthenozoospermia, and oligospermia
Background Genetic factors are candidates for about 30% of male infertility with sperm production-related abnormalities. Y chromosome microdeletions are responsible for around 10% of male infertility. These microdeletions generally occur in azoospermia factor on the Yq. That is often associated with the quantitative reduction of sperm. Objective The aim of this cross-sectional study was to de...
متن کاملY chromosome microdeletions in idiopathic infertile men from West Azarbaijan.
INTRODUCTION Although assisted reproduction techniques are used extensively in Iran, screening for Y chromosome microdeletions before intracytoplasmic sperm injection is often undervalued. Our aim was to investigate Y chromosome microdeletions in men with idiopathic azoospermia or severe oligospermia. MATERIALS AND METHODS In 99 selected patients with azoospermia or severe oligospermia and el...
متن کاملDetection of Y chromosome microdeletions and mitochondrial DNA mutations in male infertility patients.
Infertility affects about 10-15% of all couples attempting pregnancy with infertility attributed to the male partner in approximately half of the cases. Proposed causes of male infertility include sperm motility disturbances, Y chromosome microdeletions, chromosomal abnormalities, single gene mutations, and sperm mitochondrial DNA (mtDNA) rearrangements. To investigate the etiology of decr...
متن کاملMicrodeletions on the long arm of the Y chromosome and their association with male-factor infertility.
Significant advances in treatment have enabled previously infertile males to achieve fatherhood, when only a few years ago they would have had no chance of biological paternity. In contrast to the overall success of assisted reproduction, the aetiology of male-factor infertility is poorly understood. Recent studies have shown, however, that a significant proportion of men with severe infertilit...
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ژورنال
عنوان ژورنال: The Journal of Clinical Endocrinology & Metabolism
سال: 1999
ISSN: 0021-972X,1945-7197
DOI: 10.1210/jcem.84.10.6077